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KMID : 0604520190450030225
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Journal of the Society of Cosmetic Scientists of Korea
2019 Volume.45 No. 3 p.225 ~ p.235
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Skin Hydration and Skin Barrier Effects of Cymbopogon citratus and Perilla frutescens Extracts
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So Yang-Kang
Hwang Ji-Young
Kim Hyun-Woo
Jo Ha-Neul
Lee Tae-Bum
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Abstract
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Cymbopogon citratus (CC) and Perilla frutescens (PF) are known to exert various biological effects. However, their skin hydration and skin barrier effects remain unclear. This study investigated effects of their extracts on skin hydration and skin barrier and analysed the phenolic compounds. effects of these extracts on skin hydration in HaCaT cells showed that Hyaluronic acid production in cells treated with ethanol extracts was higher than that treated with water extracts for both CC and PF. HPLC was used to analyse 19 phenolic compounds in CC and PF ethanol extracts (CCE and PFE). Results revealed chlorogenic acid and p-coumaric acid in CCE and rosmarinic acid and caffeic acid in PFE. Expression levels of hyaluronan synthase 1 (HAS1), HAS2, HAS3, and aquaporin 3 (AQP3), which are related to skin moisturization, and filaggrin and loricrin, which are related to skin barrier were higher in cells treated with CCE than with PFE. CCE and PFE also increased expression of PPAR-a protein involved in skin moisturization and epidermal differentiation in a concentration-dependent manner. As major components of CCE, chlorogenic acid and p-coumaric acid increased PPAR-a protein expression. Thus, CCE and PFE could be used as functional cosmetic materials for skin hydration and skin barrier effects.
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KEYWORD
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Cymbopogon citratus, Perilla frutescens, skin hydration, skin barrier, keratinocyte 225
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